CHELATION, PHYSICOCHEMICAL AND ANTIMICROBIAL ACTIVITIES OF SOME MIXED CLOXACILLIN-VITAMIN C METAL COMPLEXES

Abstract

A new series of Ni(II), Co(II) and Mn(II) chloride complexes of mixed Cloxacillin and Vitamin C were synthesized using Refluxing method. Characterization of the ligands and their complexes were carried out by Molar conductivity, Elemental analysis and FT-Infrared spectroscopy. Antibacterial activity of the ligands and their metal complexes were investigated against selected test bacteria (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa). The stoichiometry of the reaction between the ligands and the metal ions was determined following standard procedures. Based on the mobility of ions, the complexes were non-electrolytic in nature. The percentage elemental composition of the complexes and ligands indicated that they are in good agreement with each other. The FT-IR data showed a bathochromic shift in the band of the complexes observed at 1670 cm^-1 which is attributed to nitrogen of azomethine and oxygen of carbonyl group in cloxacillin. In vitamin C, Coordination occurred through the oxygen of hydroxyl and carbonyl group. The complexes were found to be in octahedral geometry. Evaluation of antibacterial activity revealed the metal complexes to be higher in activity compared to their parent ligands implying that metal complexes possess a better affinity for bacterial plasma membrane of than their ligands. The relationship between ligands and metals  confirmed a 1:1 metal to ligand ratio in all the complexes.