Detection of Alzheimer’s Disease using CNN Architectures

Priyam Pandey, Ashish Khare, Prashant Srivastava

Abstract


Alzheimer’s disease is a neurological condition that causes some structural alterations in the brain. In this paper we have given an overview of all the available good CNN models used in medical imaging for image classification purpose such asAlexNet, GoogleNet, ResNet 18, ResNet 50, SqueezeNet and DenseNet. Using these CNN models, we have been able to classify three different stages of Alzheimer's disease – Cognitively Normal (NC), Mild Cognitive Impairment (MCI) and Alzheimer’s Disease(AD). The dataset is derived from ADNI and has been preprocessed before applying various CNN models. The experimental results demonstrate that all models performed well and the best accuracy has been acquired by the GoogleNet of 96.81%.


Full Text:

PDF

References


A.B. Rabeh, F. Benzarti and H. Amiri, "Diagnosis of Alzheimer diseases in early step using SVM (Support Vector Machine)," 2016 13th International Conference on (CGiV), 2016, pp. 364-367

F.N.Iandola, S.Han, M.W.Moskewicz, K. Ashraf, W.J.Dally and K.Keutzer, “SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <0.5MB model size”,2016, arXiv:1602.07360 [cs.CV]

K. He, X. Zhang, S. Ren and J. Sun, "Deep Residual Learning for Image Recognition," 2016 Comput Soc Conf Comput Vis Pattern Recognit , 2016, pp. 770-778

Justin S. Smith, Adrian E. Roitberg, and Olexandr Isayev, “Transforming Computational Drug Discovery with Machine Learning and AI,” ACS Medicinal Chemistry Letters 2018, vol. 9 Issue 11, pp.1065-1069

Z.Akkus, A. Galimzianova, A. Hoogi, D.L.Rubin and B.J.Erickson,“Deep Learning for Brain MRI Segmentation: State of the Art and Future Directions”, J Digit Imaging vol. 30, pp. 449–459 (2017).

A. Mahmoudi, S. Takerkart, F. Regragui, D. Boussaoud and A.Brovelli, "Multivoxel Pattern Analysis for fMRI Data: A Review",

Comput. Math. Methods Med., 2012, pp. 1-14

X.Tang, The role of artificial intelligence in medical imaging research, BJR|Open, vol. 2, Issue 1November 2020

W. Penny, K.Friston, J. Ashburner, S. Kiebel and T. Nichols, “Statistical Parametric Mapping: The Analysis of Functional Brain Images”.

R.Bellman,”DynamicProgramming”,Science,1966, vol. 153,no 3731, pp. 34-37

A. W. Salehi, P. Baglat, B. B. Sharma, G. Gupta and A. Upadhya, "A CNN Model: Earlier Diagnosis and Classification of Alzheimer Disease using MRI," 2020 International Conference on Smart Electronics and Communication (ICOSEC), vol. 2020, pp. 156-161

Z.N.K. Swati, Q. Zhao, M. Kabir, F.Ali, Z.Ali, S.Ahmed, and J.Lu, “Brain tumor classification for MR images using transfer learning and fine-tuning”, Comput. Med. Imaging Graph., vol. 75, 2019, pp. 34-46

J.Zhang , X.Li, Y.Li, M.Wang, B.Huang , S.Yao and L.Shen, “Three dimensional convolutional neural network-based classification of conduct disorder with structural MRI”, Brain Imaging Behav. vol. 14 no 6,2020 Dec; pp. 2333-2340.

Y. LeCun, P. Haffner, L. Bottou and Y. Bengio (1999),“Object Recognition with Gradient-Based Learning. In: Shape, Contour and Grouping in Computer Vision”, Lecture Notes in Computer Science, vol. 1681. Springer, Berlin, Heidelberg, pp. 319–345

S. Albawi, T. A. Mohammed and S. Al-Zawi, "Understanding of a convolutional neural network," Int. Conf. Eng. Technol(ICET)vol.2017, pp. 1-6,

X. Wang, X.Liang, Z.Jiang, B.A. Nguchu, Y. Zhou, Y.Wang, H.Wang, Y.Li, Y.Zhu, F.Wu, J. Gao and B.Qiu, “Decoding and mapping task states of the human brain via deep learning”, Hum. Brain Mapp, vol. 41, Issue6, pp. 1505-1519, April 15, 2020

J. Peng, “Understanding of the Convolutional Neural Networks with Relative Learning Algorithms.” vol. 2018, pp. 657-661

S.D., A.C.Müller,S. Behnkeand D.Scherer, “Evaluation of Pooling Operations in Convolutional Architectures for Object Recognition”, Artificial Neural Networks – ICANN 2010. vol. 6354, 2010.

C.Nwankpa, W.Ijomah, A.Gachagan and S.Marshall, “Activation Functions: Comparison of trends in Practice and Research for Deep Learning”,arXiv : 1811.03378

A.Krizhevsky, I.Sutskever and G.E.Hinton, “ImageNet classification with deep convolutional neural networks”, Communications of the ACM, vol. 60, No. 6,pp 84–90

J. Liu, Y.Pan, M. Li and Z.Chen, "Applications of deep learning to MRI images: A survey," Big Data Mining and Analytics, March 2018, vol. 1, no. 1, pp. 1-18

G.Huang, Z.Liu, L. Maaten and K.Q.Weinberger, “Densely Connected Convolutional Networks”,2018, arXiv:1608.06993 [cs.CV]

S.Bringas, S Salomón , R. Duque, C. Lage and JL Montaña,“Alzheimer's Disease stage identification using deep learning models” J Biomed Inform., 2020 Sep;vol.. 109, 103514,

Epub 2020 Jul 23

S.Klöppel, CM. Stonnington, C.Chu, B.Draganski, RI. Scahill, JD. Rohrer, NC. Fox, CR. Jack, J.Ashburner and RSJ. Frackowiak, “Automatic classification of MR scans in Alzheimer's disease”, Brain, vol. 131, Issue 3, pp. 681–689.

Gray and K.Rachel: Machine learning for image-based classification of Alzheimer’s disease. Ph.D. thesis, Imperial College London (2012)

E. Hosseini-Asl, R.Keynton and A.El-Baz, “Alzheimer's disease diagnostics by adaptation of 3D convolutional network”, 2016 Int. Conf. Image Process. (ICIP), 2016, pp. 126-130.


Refbacks

  • There are currently no refbacks.


------------------------------------------------------------------------------------------------------------------------

The ADBU Journal of Engineering Technology (AJET)" ISSN:2348-7305

This journal is published under the terms of the Creative Commons Attribution (CC-BY) (http://creativecommons.org/licenses/)

Number of Visitors to this Journal: