Nanotechnology in Cancer Detection and Treatment

Imtinungla ., Arpita Baruah, Deepti Lourembam, Sunandan Baruah

Abstract


 

Nanotechnology has taken great strides in the field of medicine with improved drug delivery systems. The application of nanoparticles in cancer detection and treatment has been prominent in recent years wherein unique properties can be utilized for detection of site specific tumors. The main objective of this review is to give an update on the available techniques and briefly describe the nano-medicines developed so far for an effective treatment. Conventional techniques face the problem of toxicity resulting from the administered drug. In addition to this, most of the techniques available detect cancer only after metastasis which hampers the effectiveness of the anti-cancer drug. Through the application of nanotechnology techniques, active cancer cells can be differentiated and treated without harming the healthy cells. This review discusses the use of nanoparticles like quantum dots and fullerenes for detection of cancer cells by acting as imaging agents. These are crucial for identifying the affected cells and tissues for effective measurement. Liposomes and dendrimers are used in treatment through development of advanced drug delivery systems. Some other nanoparticles like carbon nanotubes and magnetic nanoparticles have extended application in both imaging and treatment. Due to its wide ranging properties and diverse applications, the nanoparticles developed so far and nanotechnology as a whole has a huge potential in cancer treatment.


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References


M. Jahan Ara, ―Nanotechnology Fights Cancer and gives New Hopes For Life‖Department of Zoology Osmania College, Kurnool, (vol3) pp. 1-3 Issue 1, Jan-Mar 2013

Available:https://en.wikipedia.org/wiki/Cancer.[Accessed: February 25, 2017]. (General Internet Site)

M. Sethi, S. K. Chakarvati, ―Hyperthermia Techniques for cancer treatment: A Review‖ International Journal of PharmaTech Research (vol8), pp. 292-299, 2015

Available:http://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer#heading [Accessed: February 26, 2017] (General Online Site)

V. Tischlerova, A. Valencakova, ―Use of Nanotechnology in the Diagnosis, Prevention and Therapy of Cancer‖ International Journal of Pharmaceutical Sciences and Drug Research, (vol7), pp. 01-07, 2015

S.Laurent and M.Mahmoudi, ―Review article: Superparamagneticiron oxide nanoparticles: promises for diagnosis and treatment of cancer‖ Int J Mol Epidemiol Gene, pp. 367-390, 2011

M. Guirguis, ―Cancer and Nanotechnology‖ Biomedical Engineering, University of Rhode Island, March 14, 2013

K. M. K. Masthan, N. A. Babu, K. T. Shanmugam, A. Jha, ― Nanotechnology: Its Application in Oral Cancer‖, Journal of clinic and diagnostic research, (vol6), pp.1328-1330, 2012

C. J. Hu, S. Aryal, L. Zhang, ―Nanoparticle-assisted combination therapies for effective cancer treatment‖ University of California San Diego, Therapeutic therapy, (vol1), pp. 323-334 , 2010

S.A. Mousa and D. J. Bharali, ―Nanotechnology-based detection and Targeted Therapy in Cancer:Nano-Bio Paradigms and Applications‖ [Online] Available: www.mdpi.com/jpurnal/cancers ISSN 2072-6694 [Accessed: January 16, 2017]

J. Chen, R. Shao, X. D. Zhang, C. Chen, ―Applications Of NanotechnologyFor Melanoma Treatment, Diagnosis and Theranostics‖ University of Wollongong Research Online

G. A. Mansoori, P. Mohazzabi, P. McCormack, S.Jabbari, ―Nanotechnology In Cáncer Prevention, Detection and Treatment: Bright Future Lies Ahead‖ World Review of Science,

Technology and Sustainable Development, (vol4), 2007

―Going Small for Big Advances: Using Nanotechnology to Advance Cancer diagnosis, Prevention and Treatment‖ U>S>Department of Health and Human Services, National Institute of Health, National Cancer Institute, January 2014

T. J. Harris, G. V. Maltzahn and S. N. Bhatia, ―Multifunctional Nanoparticles for Cancer Therapy‖ pp. 59-75, 2007

M. Fang, C. Peng, D. Pang, Y. Li, ―Quantum Dots For Cancr Research: Current Status, Remaining Issues And Future Perspective‖ Cancer Biol Med, (vol9), pp. 151-163, 2012

P. Malik, S. Gulia, R. Kakkar, ―Quantum dots for diagnosis of cancer‖ [online] Available: www.amlett.com, www.amlett.org, [Accessed: January 16, 2017]

C. Peng and Y. Li, ― Application Of Quantum Dots Based Biotechnology In Cancer Diagnosis: Current Status And Future Perspective‖ Journal of Nanomaterials, 2010

M. L. Asha, L. Ghorai, B. N. Rajaranthnam. Et al, ―CarbonNanotubes: A Novel Approach For Cáncer Diagnosis And Therapy ‖ Journal of Orofacial Research, pp. 84-89, 2015

C. Dianzani, G. P. Zara, G. Maina, et al ―Drug Delivery Nanoparticles In Skin Cancer‖ BioMed Research International, pp. 1-13, 2014

Y. Choi, J. Kwak and J. W. Park, ―Nanotechnology for early Cancer Detection‖ Sensors, pp.428-455, 6 January 2010

C. S. Sindura, N. C. Babu, Vinod, ―Un-bounding the future: Nano-biotechnology in Detection and Treatment of Oral Cancer‖, pp. 66-79, 2013

J. Conde, G. Doria, and P. Baptista, ―Noble Metal Nanoparticles Applications in Cancer‖ Journal of drug delivery, (vol2012), pp. 1-12, 2011

R.Vaidyanathan, K.Kalishwaralal, S. Gopalram, S.Gurunathan, ―Nanosilver—The Burgeoning Therapeutic Molecule And Its Green Synthesis‖ Biotechnology Advances, pp. 924-937, 2007.

S. Jain, D. G. Hirst And J.M.O’sullivan, ―Gold Nanoparticles As Novel Agents For Cancer Therapy‖ The British Journal of Radiology, (vol85), pp. 101–113, 2012

W.Bhati, A.Vishwa, ―Nanotechnology Method Comparision for Early Detection of Cancer‖ I.J. Intelligent Systems and Applications, (vol3),pp. 58-65, 2013

J. R. Baker Jr., ―Dendrimer Based Nanoparticles For Cancer Therapy‖ American Society of Haematology, pp. 708-719

Etheridge and M.L, ―Understanding the Benefits and Limitations of Magnetic Nanoparticle Heating for Improved Applications in Cancer Hyperthermia and Biomaterial Cryopreservation: Dissertation‖ [Online] Available: http://adsabs.harvard.edu/abs/2013PhDT........98E [Accessed: January 20, 2017]

T. Kobayashi and H. Honda, ―Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses‖ in Hyperthermic Oncology from Bench to Bedside, Springer Singapore, 2016.

M. F. Tang, L. Lei, S. R. Guo and W.L. Huang, ―Recent Progress In Nanotechnology For Cáncer Therapy‖ Chinese Journal Of Cáncer, (vol 29), pp. 775-780, 2010

D. Darmawikarta, A. Pazionis, ―Nanotechnology In Cáncer Therapeutics‖ UWOMJ, pp.20-21, 2013


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